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Quercetin was found to inhibit androgen-induced expression of genes related to lipid synthesis in sebaceous gland cells, and quercetin may also inhibit the conversion of testosterone to dihydrotestosterone (DHT) by suppressing 5α-reductase activity, consequently reducing DHT’s stimulatory effect on sebaceous gland cells, decreasing the secretion of sebum, and ameliorating the symptoms of acne ( However these studies of sebaceous gland cells may be limited by the complexity and heterogeneity of the cells, which makes it difficult to resolve the spatial and molecular relationships of sebaceous gland cells at different stages of differentiation