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Inflammatory cytokines, including TNF, have also been shown reduce glutamine synthetase, which converts glutamate to glutamine, potentially leading to a buildup of intracellular and extracellular glutamate concentrations, which along with cytokine induction of nitrogen and oxygen free radicals (and oxidative stress), can lead to astrocyte death (Kazazoglou et al., 1996
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Additionally, TST contributes to the thiol-dependent antioxidant system by regulating reactive sulfur species and sustaining mitochondrial functionality through its role in sulfide-driven bioenergetics
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