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Such an effort led to the discovery of two additional platinum derivatives that are nowadays approved by FDA for use in cancer patients: cis -diammine (cyclobutane-1,1-dicarboxylate- O , O ′) platinum(II) (carboplatin) and [(1 R ,2 R )-cyclohexane-1,2-diamine](ethanedioato- O , O ')platinum(II) (oxaliplatin)
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The most common critical flaws included a failure to register a protocol a priori (Q2), not providing a list of excluded studies with justification (Q7), failing to discuss the likely impact of risk of bias on the results (Q12), and not adequately reporting on conflicts of interest (Q15) (Figure 3)
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Keep missing information visible instead of filling it with guesses. Use the table to support judgment rather than replace it.
Consider whether an acceptable alternative could meet the same purpose. Avoid allowing a short deadline to erase an essential requirement.
Use a cropped view when it fully supports your intended point. Keep enough context to avoid misrepresenting the information shown.
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