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subsequent growth hormone exposure increased cell proliferation and activated JAK2, the downstream GHR signaling pathway β suggesting BPC-157 sensitizes tendon tissue to endogenous growth hormone (PMID 25415472) Wound and Fistula Closure: A 2021 review documents closure of skin defects and both external and internal fistulas (esophagocutaneous, gastrocutaneous, duodenocutaneous, colocutaneous, colovesical, rectovaginal) in rat models at 10 ΞΌg/kg or 10 ng/kg given intraperitoneally or orally in drinking water, with the beneficial effect maintained under NO-system manipulation (PMID 34267654) Gastrointestinal: Anti-ulcer activity across esophagus, stomach, duodenum, intestine, liver, and pancreas lesion models
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