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The proposed pathogenic mechanism involves increased androgen receptor (AR) expression in scalp hair follicle (HF) cells, resulting in hypersensitivity to testosterone derivatives [37]
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In one placebo-controlled study with 75 ulcerative colitis patients, 100 mg saffron daily for eight weeks improved clinical activity index scores, total antioxidant capacity, and increased levels of the antioxidant enzymes superoxide dismutase and glutathione peroxidase compared with placebo (Tahvilian 2021)
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