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By now you will have gathered that declining glutathione levels can have a significant impact on the body’s defense mechanisms

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As a key product of the pentose phosphate pathway, NADPH strengthens cellular antioxidant defenses by driving the regeneration of reduced glutathione ( However, overexpression of Pfkfb3 activates glycolysis in neurons through the APC/C-Cdh1 pathway, which inhibits the pentose phosphate pathway (PPP), reduces the oxidation of glucose-6-phosphate (G6P), decreases the production of reduced glutathione, and finally leads to oxidative stress and apoptosis (Herrero-Mendez et al., 2009)