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Before cytokine stimulation, cultures were pre-treated for 1 h with 25 μM 6-amino-1,4-dihydro-4-[5-(hydroxymethyl) (SHIN1), a serine hydroxymethyltransferase 1 and 2 (SHMT1/SHMT2) inhibitor (MedChemExpress, Monmouth Junction, NJ, USA), IUPAC name: 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile) [22]
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