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SIRT3 has been shown to deacetylate and activate mitochondrial IDH2 to increase mitochondrial NADPH production [259], while the FOXO3 transcriptional regulator increases PPP flux to increase cytoplasmic NADPH [260]
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10.1016/j.exer.2015.10.005 111 SugitaS.MandaiM.KamaoH.TakahashiM
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