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Where semaglutide (Ozempic/Wegovy) acts on GLP-1 alone, Tirzepatide's dual activity is associated with stronger outcomes in clinical research: Phase 3 SURMOUNT trials reported mean body weight reductions of up to 22.5% over 72 weeks — one of the largest figures documented in weight-management research
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Despite substantial experimental evidence supporting this notion, challenges such as low solubility, limited bioavailability, and BBB impermeability hinder efficient delivery of EGCG to the brain and impede clinical translation (173)
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