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Pre-injection preparation can substantially reduce bruising: Allow the Trulicity pen to reach room temperature (approximately 30 minutes out of refrigeration) before injection for comfort [2] Cleanse the injection site with an alcohol wipe and allow it to dry completely —injecting through wet alcohol can increase discomfort Visually inspect the injection area, avoiding sites with visible blood vessels near the surface Never inject through clothing Avoid areas where clothing waistbands or elastic may cause friction Correct Trulicity pen technique includes: Unlock the grey base by turning it Place the clear base flat against the skin at a 90-degree angle Press and hold the green injection button Listen for the first click, then continue holding until you hear the second click (this may take up to 5-10 seconds) Remove the pen from the skin after the second click Post-injection care involves applying gentle pressure (without rubbing) using a clean cotton wool ball or gauze for 5–10 seconds

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