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Taking into account that PV and related neoplasms are chronic blood cancers, which — like any other untreated cancer — will steadily progress due to clonal expansion and evolution, we would like to underscore the urgent unmet need to initiate stem-cell targeting treatment with IFN- α alongside treatment targeting the chronic inflammatory state, which not only drives the malignant MPN-clone but also likely accelerates development of atherosclerosis and accordingly cardiovascular diseases and — important — second cancers in MPNs as well (328)

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