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For example, stimulation of group II metabotropic glutamate receptor and blockade of group I metabotropic glutamate receptor could prevent relapse of cocaine, heroin, nicotine, and alcohol (84–90)
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73 Under the condition of hypoxia at high altitude, mitochondrial function is inhibited, resulting in abnormal mitochondrial energy metabolism and excessive production of ROS, leading to brain oxidative stress damage and inducing the occurrence of HACE
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