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IGF-DES
doi:10.1126/science.321.5887.326
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Mechanistic considerations A fundamental concept underpinning drug-specific T-cell responses is the pharmacological interaction (p-i) model, which posits that certain small-molecule drugs can noncovalently interact with T-cell receptors (TCRs) and human leukocyte antigen (HLA) molecules, thereby activating antigen-specific T cells (39)
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