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gene expression research exploring modulation of aging-associated pathways Genomic modulation — Connectivity Map (CMap/Broad Institute) analyses investigating the transcriptional signature of GHK-Cu across a broad set of human genes Pulmonary protection — preclinical models examining potential reversal of gene expression patterns associated with COPD Neurobiological function — studies investigating GHK influence on genes relevant to nervous system function and copper metabolism in neurodegenerative disease models Oncology research (experimental) — in vitro analyses of gene expression modulation in breast (MCF7) and prostate (PC3) cancer cell lines — mechanistic, not efficacy data Primary mechanism: GHK chelates Cu²⁺ and delivers it in bioavailable form to target cells, potentially via endocytosis mediated by the LRP-1 receptor

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