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Additionally, a 2026 study revealed that colon cancer patients with high B12 concentrations survived a median of about five years, compared to nearly eleven years for those with normal levels
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Higher NAD⁺ enhances SIRT1 activity, promoting fat oxidation and mitochondrial remodeling via PGC-1α pathways—mechanisms consistent with improved endurance and recovery potential (Cantó et al., Cell Metabolism
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