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Animal studies show substantial evidence across stroke models (full functional recovery in spatial memory, motor coordination, balance), Parkinson’s models (protection of dopaminergic neurons, near-complete prevention of mortality), multiple sclerosis models (significantly less brain damage), and traumatic brain injury (reduced hemorrhage and edema)

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To accentuate all the disturbances, and to emphasize the obtained therapeutic effectiveness, we used a cuprizone regimen several times higher than those regularly used in cuprizone studies [31,155]