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Consequently, much higher concentrations of pegvisomant are necessary to reduce serum IGF1 in mice
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In cisplatin-induced AKI, SS-31 may exert antioxidative stress and antiapoptotic effects by modulating mtROS production, downregulating the NLRP3-IL-1 β /caspase 1 signaling pathway, ameliorating cisplatin-induced acute tubular necrosis, and reducing Scr and blood urea nitrogen (BUN), but not body weight, renal weight, serum albumin, and triglycerides [37]
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