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Once seen as an inevitable consequence of ageing, senescence is now recognized as a modifiable driver of kidney inflammation, fibrosis, and functional decline
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finds that inhibition of SLC7A11 after Erastin treatment increases radiosensitivity in SLC7A11 + breast cancer cells in vitro and in vivo , while it has no effect on SLC7A11 - cancer cells, this process accompanied by a decrease in intracellular GSH synthesis that promotes cell death (Cobler et al., 2018)
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