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Here we investigate the allosteric regulation of the mammalian glutamate dehydrogenase GDH and show how the Guanosine triphosphate (GTP) binding establishes allosteric communication with the regulatory coenzyme NADH which then synergistically inhibits the oxidative deamination activity of GDH by stabilizing its closed conformation

Carnitine plays a critical role in fat metabolism in heart and skeletal muscle tissue where fat conversion to energy is required most.