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It is well documented that chemicals which release ROS such as metals ( Reference He, Lin, Chen, Zhang and Ma 116 , Reference He, Chen, Lin and Ma 117 ) and vascular diseases (arteriosclerosis, diabetes, chronic renal failure, preeclampsia) both cause induction of the different transcription factors described above ( Reference Mann, Niehueser-Saran, Watson, Gao, Ishii, de Winter and Siow 118 )