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2019)with damage footprints (F 2 -isoprostanes, nitrotyrosine, protein carbonyls, 8-oxoG) and iron metrics (calcein-quench assays of the labile iron pool with chelator validation, plus ferritin/HO-1/ferritinophagy markers) (Riedelberger and Kuchler 2020)
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Tryptophan catabolism can also be initiated within non-hepatic tissues by the enzyme indoleamine 2,3-dioxygenase 1 encoded by the IDO1 gene
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