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mechanism of action of l-carnitine The Role in Mitochondria, Prevention Metabolic Inflexibility and Disease Initiation Abib Glutathiosome Dark Spot
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Colon cancer stem cells also utilize autophagy for resistance: CD 44+ CD 24+ Cdx 1+ cells demonstrate high Bcl-2 and LC3-II/I ratios, resisting paclitaxel-induced death, while Cdx1 silencing or lysosomal inhibition sensitizes them, contrasting with p53-driven apoptosis and autophagy suppression in CD 44+ CD 24+ p53wt cells (57)
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