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In a chronic social defeat stress model in mice, 21 days of oral administration at 0.1 mg/kg corrected depressive-like behavior, restored motor activity with a therapeutic effect of 60 percent, completely recovered anhedonia, restored synaptophysin levels (74 percent therapeutic effect), and fully restored CREB levels in the hippocampus
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doi: 10.1016/j.tem.2021.11.003 [DOI] [PubMed] [Google Scholar] 181.Mushtaq Z, Imran M, Saeed F, et al
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