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Furthermore, the SLC7A11 gene, which is often significantly downregulated in PD, is also considered a critical regulator of ferroptosis and can protect dopaminergic neurons by activating the transsulfuration pathway, indicating a potential interplay with DJ-1 (93)

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While this is most likely the consequence of respiratory failure, both IGF-1 and IGF-1R knockout mice exhibit central nervous system deficits compared to control animals