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However, “generally excreted” does not mean “entirely without consequence.” Emerging research has raised questions about whether chronically elevated serum B12 levels may serve as a marker for underlying conditions or could be associated with certain health concerns

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Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet