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LPS can exacerbate lipid metabolism by binding to Toll-like receptor 4 (TLR4), a receptor expressed on macrophages, hepatocytes and adipocytes, and inducing the secretion of pro-inflammatory factors like interleukin 6 (IL-6) and monocyte chemotactic protein 1 (MCP-1)
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Because they also possess selenium-independent GPx activity, GSTs are able to reduce hydroperoxides of phospholipids and free fatty acids as well as cholesterol hydroperoxides [17,18,19]
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