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Tumor cells expand mitochondrial adaptive reserve to resist stress and acquire therapeutic tolerance, whereas the common directionality of Sch B across multiple tumor models is compression of this mitochondrial adaptive reserve: by increasing oxidative burden to approach mitochondrial tolerance limits, disrupting ΔΨm and energy homeostasis to enhance the triggerability of death pathways, or weakening resistance-associated threshold-elevation mechanisms to potentiate therapeutic cytotoxicity
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A recent review exploring evidence obtained by neuroimaging studies of individuals with prodromal, first episode, and chronic schizophrenia demonstrated regional differences in neurotransmitters, including glutamate, GABA, and dopamine
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