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Instead, pyruvate is reduced to lactate by LDHA, allowing for NAD + regeneration and sustained glycolysis 13,105,106
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By mimicking this phosphorylated state, the S249/T252 peptide aims to disrupt the RB-NF-κB interaction and inhibit NF-κB-mediated PD-L1 transcription, thereby strengthening cancer immunity and overcoming immune evasion mechanisms triggered by both conventional and targeted therapies (Jin et al., 2019)
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