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A possible explanation for these studies is that alterations in SCFA content in AS patients lead to impaired Treg function, which results in activation of the IL23-IL17/22 axis and dysregulation of mucosal cells involved in type 3 immunity and regulated by RORγt (e.g., ILC3, invariant natural killer T (iNKT) cells, MAIT cells, and γδ-T cells) (147)
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