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(19) showed that TNF-β induction could make chondrocytes produce a pro-inflammatory microenvironment similar to that of TNF-α and T lymphocytes, up-regulate the pro-inflammatory signaling pathway and inhibit the chondrogenic potential of chondrocytes, while resveratrol could inhibit the downstream signaling pathway of TNF-β, which might be achieved by inhibiting the NF-κB signaling pathway of chondrocytes and up-regulating the SIRT1 signal
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