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In conclusion, the hypoxia–HIF‐1α–VEGF pathway regulates inefficient vasculature, which sustains tumor cell metabolism, facilitates dissemination, and reinforces immunosuppression (117, 118)
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Thus, when diseases of pre-puberty result in production of ROS through, for example, a protective inflammatory response, the consequence would be survival to reach a reproductive age
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Consider whether an acceptable alternative could meet the same purpose. Avoid allowing a short deadline to erase an essential requirement.
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