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In a flask were placed 6-bromo-7-fluoro-2-|(4.S)-4-hydroxy-2- (methoxymethoxy)pentyl]isoquinolin-l-one (0.624 g, 1.61 mmol), 5-chloro-4-(trifluoromethyl)-2-(2- trimethylsilylethoxymethyl)pyridazin-3-one (0.881 g, 2.41 mmol), DIPEA (0.84 mL, 4.82 mmol), and DMF (8 mL)
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