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The circulation of symptoms and signs varies on the nerves affected in DNP, in which most common forms are distal symmetric polyneuropathy and pain, and sensory findings are observed in the feet, toe, and occasionally also in the finger of hands (Prajapati, Filippi, & Sears, 2021)

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Those reactions are more concerning if they worsen, spread, become hot, drain fluid, or come with fever or systemic symptoms