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363,364 A second 5- exo-trig cyclization forms a bicyclic endoperoxide and creates mostly a cis -configuration between the two lateral chains
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Furthermore, because some NAPQI is created regardless of the function of the other 2 pathways, failure in the glutathione-dependent pathway is expected to result in the accumulation of NAPQI and subsequent toxicity, even if the other 2 pathways are functional.It is not surprising that both sulfation- and glutathione-dependent pathways are aberrant in the same population because they are metabolically connected [41,72,73]
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