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The results showed that cells with suppressed GPX3 expression were more susceptible to cell death induced by ascorbate, indicating that GPX3 expression is crucial for scavenging excessive extracellular H2O2
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found that amplifying hypoxia-inducible factor (HIF) signaling pathways triggered ferroptosis in chemotherapy-resistant GBM cells and suppressed tumor growth in animal models, suggesting that inducing ferroptosis by targeting HIF-α could improve GBM treatment
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