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On the one hand, disruption of these neurotransmitter metabolisms can result in the loss of innervation of monoamine neurons in the brain and induces depressive behaviors such as mood disorders ( 3.1.2 Triggering neuroinflammation following BBB disruption Neuroinflammation was mediated by the activation of microglial cells ( The blood-brain barrier (BBB) is formed by endothelial cells sealed by tight junction proteins, pericytes, and astrocytes
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Thus, blocking Gln metabolism could improve the effectiveness of various cancer treatments that target different pathways ( Figure 3 )
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