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GH accelerates oncogenic signaling for common oncogenic processes and tumor development, including proliferation, migration, invasion (Brunet-Dunand et al., 2009), metastasis (Brittain et al., 2017), and epithelial-to-mesenchymal transition (EMT) (Mukhina et al., 2004), and prevents apoptosis by exerting autocrine or paracrine effects on cancer cell behavior and neighboring cells within the tumor microenvironments (Perry et al., 2017)

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They are also used to treat fluid retention in patients with edema (swelling), cirrhosis, and heart failure