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The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions
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Although intracellular Cys is not only provided by System X c − , but also by transsulfuration pathway ( c − is dysfunctional, it will still lead to intracellular Cys deficiency, and GSH depletion, making the cell highly sensitive to ferroptosis
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