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At the microbial interaction level, probiotics primarily enhance gut microbiota composition through strategies such as “competitive exclusion” and “microbial remodeling.” At the host cell interaction level, probiotics directly engage with intestinal epithelial cells, EGCs, and immune cells, secreting signaling molecules to modulate their functions, thereby affecting the ENS
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Funding This work was supported by the European Community under Innovative Medicines Initiative (IMI) Program (Grant No
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