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The liver-adipose axis In fasted state, TG in adipocyte undergoes lipolysis into non-esterified fatty acids (NEFA) and glycerol, and then, they release into the circulation and enter into the liver, NEFA are oxidized to mitochondrial acetyl CoA through Ξ²-oxidation in hepatocyte, acetyl CoA is an allosteric activator of pyruvate carboxylase, which further drives gluconeogenic flux
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