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Our prior study infusing IGF-1 LR3 into normally grown late-gestation fetal sheep that resulted in increased fetal growth but decreased fetal insulin secretion used a dose of 6.6 µg·kg −1 ·h −1 based on an estimated fetal weight of 3.5 kg (final average LR3 dose 5.23 µg·kg −1 ·h −1 based on average actual fetal weight of 4.42 ± 0.14 kg) (25)
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Physiol 476:279–93 [DOI] [PMC free article] [PubMed] [Google Scholar] 20.Behrens PF, Franz P, Woodman B, Lindenberg KS, Landwehrmeyer GB
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