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For the assessment of AFA compound inhibitory effect, a few microliters of concentrated avocadene acetate preparation (Sigma) in DMSO-d6 (Cambridge Isotope Laboratories) were also added to the mentioned D 2 O solutions, setting avocadene acetate concentration at 20 ยตM and 50 ยตM
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For example, tumors express irregular and tortuous vasculature, while ischemia is the lack of functional vessels, creating hypoxic environments and ultimately leading to tissue death
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