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The pathophysiology of AD is complex, combining genetic predisposition and impaired epidermal barrier function with an unbalanced inflammatory response to environmental factors (1, 18)

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* Correspondence: Fang Bian, [email protected] † These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers