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After measuring the peak concentrations and area under the curve of GH and IGF-1, researchers found that CJC-1295 increased mean plasma GH concentrations by 2- to 10-fold for 6 days or more, and increased mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 days
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Concurrently, this ROS burst activates the NF-κB pathway, perpetuating pro-inflammatory cytokine secretion (TNF-α, IL-1β, IL-6) and establishing a vicious cycle of chronic inflammation
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