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117 found that angiotensin II(Ang II) enhanced the activity of class I HDAC1/2, reduced histone acetylation of H3K9/14ac and H4K8ac, further inhibited Npr1 (encoding natriuretic peptide receptor-A) transcription, and decreased natriuretic peptide receptor-A protein and cGMP levels, thereby diminishing renal and vascular reactivity and attenuating atrial natriuretic peptide-mediated aortic ring relaxation
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Comparison with the effects of GHRH, TRH and HCRH
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