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So the current criteria involve two scores: The Widespread Pain Index (WPI) , which counts how many body areas have been painful The Symptom Severity Scale (SSS) , which rates fatigue, waking unrefreshed, and cognitive problems, plus other symptoms On top of that, the pain needs to be present in at least four of five body regions (left upper, right upper, left lower, right lower, and axial, meaning neck and back), and symptoms need to have been generally present for at least three months

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Folate insufficiency was one of these three variables that had the most impact on the serum tHcy levels, followed by MTHFR C677T and vitamin B12 deficiency (in decreasing order of impact) [48]

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