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Interestingly, whereas all five control C57BL/6N mice at 17 months of age showed many light-colored spots in their fundus, two and four out of five mice at 100 and 300 mg/kg/day doses, respectively, showed dramatic reduction in these spots, implicating that age-associated pathological changes caused by the rd8 mutation may be suppressed by NMN in C57BL/6N mice (Figure 6A)

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