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PDF) A case of severe glutathione synthetase deficiency with novel GSS mutations

These molecular interactions – the interactome as shown in Figure 4 – occur across bronchial epithelial cells, dendritic cells, macrophages, innate lymphoid cells, CD4+ naïve T cells, Th1 cells, Th2 cells, Th17 cells, Treg cells, CD8+ T cells, eosinophils, neutrophils, B cells, mast cells, basophil, ASMC, fibroblasts, myofibroblast, endothelial cells, pericytes, microglia, adrenal cortex and medulla cells, mucosal gland cells, neurons such as PVN of hypothalamus, amygdala brain neurons, brainstem neurons, pituitary neurons, sympathetic neurons, afferent vagal sensory neurons, efferent parasympathetic cholinergic and noncholinergic neurons

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exquisitely well grown and without undesirable tagalongs), then the cell may be able to adequately absorb both physical nutrients as well as the nutrient’s resonant frequencies, allowing the cell to function at its optimal frequency.* IMMUNE PRIMERS* Garlic Extract (Allicin), Reishi (Beta glucan), Vitamin C,** Vitamin D,** Zinc,** Selenium,** B Vitamins** Exciting research demonstrates that a comprehensive strategy that administers specific immune-potentiating botanicals can clinically prime the body’s natural defense mechanisms during stressful periods when immune specific concerns are present.* ● Recent studies confirm that vitamin D helps modulate the inflammatory response of an already healthy immune system during times of stress.* In addition, ensuring that vitamin D levels are adequate may be critically important to help activate immune cells in order to promote a healthy immune response.* ● Garlic may promote critical responses of the innate immune system and also plays an essential role in the adaptive immune response during times of stress.* ● Studies have shown that consuming specific mushroom compounds, such as the unique immune compound, beta glucans, supports immune function and also generally promotes the maturation and activation of both the innate and adaptive immune systems.* ● Vitamin C helps modulate the immune cells’ healthy inflammatory response by actively transporting vitamin C into cells during times of stress.* ● Zinc interacts with cellular ligands to support internal cell signaling, an important component to both innate and adaptive immunity.* ● B Vitamins play important roles in nearly all of the body’s functional systems.* Some of the wide-reaching supportive roles of B vitamins include the health of the nervous system, support for liver, skin and hair as well as maintaining muscle tone in the gastrointestinal tract.* A sufficient level of B vitamin intake is essential to maintain adequate immune system health, energy metabolism, mood balance, hormone synthesis, hemoglobin formation and proper nerve cell impulse transmissions.* ENERGY DRIVERS* Plant-Source B Vitamins (two preferred forms of B12), MCT, and Fulvic Acid It is the coenzymes of vitamin B12, as methylcobalamin and adenosylcobalamin, that synergize with other B vitamins to support DNA and red blood cell health.* Through a series of biochemical reactions with homocysteine, these coenzyme factors of vitamin B12 are not only important to energy metabolism but are critical to the methionine synthase pathway, supporting healthy homocysteine metabolism and S-adenosylmethionine (SAMe) production.* In this era of “more is more,” many tasks can vie for your attention and pull you in different directions all too often