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Appendicular skeletal muscle exhibits an extrapulmonary phenotype, where under conditions of chronic energy deficiency and oxidative stress, mitochondrial abnormalities are more likely to be associated with apoptosis, mitophagy imbalance, and increased susceptibility to ferroptosis
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Additional endogenous metabolites carried by the MRP1 carrier include the glutathione S -conjugates of prostaglandin (PG)A2, 15-deoxy-Δ 12,14 -PGJ 2 , and hydroxynonenal (Cole and Deeley 2006)
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