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Several dipeptidases appear to perform this reaction in the extracellular space, and carnosine dipeptidase (CNDP) 2 has been identified as a protein that preferentially reacts on the Cys-Gly dipeptide in yeast [129]
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As a result, B 2 deficiency can trigger functional folate deficiency, especially in carriers of MTHFR mutations associated with reduced activity of the MTHFR enzyme
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